What formula is used to calculate the Severity Scoring for my Antigen Assay?
ROSALIND DxM has worked closely with the FDA and NIH to develop a scoring methodology that provides guidance while interpreting the DxM in-silico modeling.
The following tables break down the method used to calculate the severity scoring for an Antigen Assay on ROSALIND. If you would like more information, please feel free to contact support@rosalind.bio
| AA changes |
| on CDC list |
| S:S13I |
| S:H69- |
| S:V70- |
| S:W152C |
| S:Y144- |
| S:K417N |
| S:K417T |
| S:L452R |
| S:E484K |
| S:S494P |
| S:501Y |
| S:A570D |
| S:D614G |
| S:P681H |
| S:A701V |
| N:M1X |
| N:D3L |
| N:P67S |
| N:R203K |
| N:R203M |
| N:T204R |
| N:T205I |
| N:M234I |
| N:S235F |
| N:D377Y |
| N:D399N |
| N:D399Y |
| N:D399H |
| N:D399E |
| N:D399G |
| Accessible positions for | |
| N protein | S protein |
| 1 | 17 |
| 2 | 18 |
| 3 | 19 |
| 4 | 20 |
| 5 | 21 |
| 6 | 22 |
| 7 | 23 |
| 8 | 24 |
| 9 | 25 |
| 10 | 26 |
| 11 | 27 |
| 12 | 28 |
| 13 | 30 |
| 14 | 40 |
| 15 | 46 |
| 16 | 52 |
| 17 | 59 |
| 18 | 61 |
| 19 | 66 |
| 20 | 67 |
| 21 | 68 |
| 22 | 69 |
| 23 | 70 |
| 24 | 71 |
| 25 | 77 |
| 26 | 80 |
| 27 | 82 |
| 28 | 83 |
| 29 | 85 |
| 30 | 87 |
| 31 | 88 |
| 32 | 92 |
| 33 | 95 |
| 34 | 99 |
| 35 | 100 |
| 36 | 108 |
| 37 | 109 |
| 38 | 112 |
| 39 | 113 |
| 40 | 114 |
| 41 | 117 |
| 42 | 118 |
| 43 | 119 |
| 44 | 120 |
| 45 | 122 |
| 46 | 123 |
| 47 | 124 |
| 48 | 129 |
| 49 | 131 |
| 60 | 132 |
| 62 | 134 |
| 66 | 135 |
| 68 | 137 |
| 75 | 138 |
| 77 | 140 |
| 78 | 141 |
| 80 | 142 |
| 81 | 148 |
| 82 | 155 |
| 93 | 157 |
| 94 | 158 |
| 95 | 159 |
| 96 | 161 |
| 98 | 163 |
| 99 | 164 |
| 101 | 165 |
| 102 | 167 |
| 103 | 168 |
| 104 | 169 |
| 120 | 171 |
| 121 | 176 |
| 123 | 182 |
| 127 | 184 |
| 129 | 187 |
| 137 | 188 |
| 138 | 194 |
| 140 | 195 |
| 141 | 198 |
| 142 | 202 |
| 143 | 207 |
| 145 | 209 |
| 146 | 211 |
| 151 | 212 |
| 152 | 213 |
| 153 | 214 |
| 154 | 217 |
| 156 | 218 |
| 159 | 222 |
| 161 | 232 |
| 163 | 234 |
| 164 | 236 |
| 165 | 237 |
| 167 | 239 |
| 170 | 240 |
| 173 | 243 |
| 174 | 244 |
| 175 | 245 |
| 176 | 246 |
| 177 | 251 |
| 178 | 253 |
| 179 | 255 |
| 180 | 261 |
| 181 | 262 |
| 182 | 263 |
| 183 | 264 |
| 184 | 265 |
| 185 | 271 |
| 186 | 272 |
| 187 | 276 |
| 188 | 279 |
| 189 | 280 |
| 190 | 281 |
| 191 | 282 |
| 192 | 286 |
| 193 | 290 |
| 194 | 292 |
| 195 | 294 |
| 196 | 295 |
| 197 | 296 |
| 198 | 303 |
| 199 | 304 |
| 200 | 307 |
| 201 | 308 |
| 202 | 309 |
| 203 | 310 |
| 204 | 314 |
| 205 | 316 |
| 206 | 320 |
| 207 | 321 |
| 208 | 323 |
| 209 | 324 |
| 210 | 325 |
| 211 | 331 |
| 212 | 333 |
| 213 | 334 |
| 214 | 335 |
| 215 | 337 |
| 216 | 339 |
| 217 | 341 |
| 218 | 343 |
| 219 | 344 |
| 220 | 345 |
| 221 | 352 |
| 222 | 354 |
| 223 | 356 |
| 224 | 360 |
| 225 | 362 |
| 226 | 364 |
| 227 | 366 |
| 228 | 367 |
| 229 | 370 |
| 230 | 371 |
| 231 | 372 |
| 232 | 373 |
| 233 | 375 |
| 234 | 376 |
| 235 | 377 |
| 236 | 378 |
| 237 | 380 |
| 238 | 381 |
| 239 | 385 |
| 240 | 386 |
| 241 | 387 |
| 242 | 389 |
| 243 | 391 |
| 244 | 401 |
| 245 | 404 |
| 246 | 405 |
| 247 | 406 |
| 248 | 407 |
| 249 | 408 |
| 250 | 409 |
| 251 | 410 |
| 252 | 413 |
| 253 | 415 |
| 254 | 418 |
| 255 | 419 |
| 256 | 420 |
| 257 | 421 |
| 258 | 422 |
| 263 | 424 |
| 266 | 426 |
| 267 | 427 |
| 271 | 437 |
| 272 | 439 |
| 276 | 440 |
| 279 | 448 |
| 280 | 449 |
| 281 | 450 |
| 282 | 451 |
| 289 | 455 |
| 293 | 459 |
| 299 | 462 |
| 302 | 466 |
| 324 | 467 |
| 326 | 469 |
| 327 | 470 |
| 334 | 471 |
| 338 | 473 |
| 340 | 475 |
| 341 | 477 |
| 342 | 480 |
| 344 | 487 |
| 345 | 488 |
| 347 | 489 |
| 348 | 490 |
| 351 | 491 |
| 354 | 494 |
| 355 | 496 |
| 361 | 498 |
| 362 | 499 |
| 364 | 500 |
| 365 | 501 |
| 366 | 503 |
| 367 | 505 |
| 368 | 507 |
| 369 | 518 |
| 370 | 522 |
| 371 | 523 |
| 372 | 525 |
| 373 | 527 |
| 374 | 531 |
| 375 | 532 |
| 376 | 534 |
| 377 | 536 |
| 378 | 537 |
| 379 | 539 |
| 380 | 540 |
| 381 | 544 |
| 382 | 545 |
| 383 | 552 |
| 384 | 553 |
| 385 | 554 |
| 386 | 555 |
| 387 | 556 |
| 388 | 557 |
| 389 | 558 |
| 390 | 559 |
| 391 | 561 |
| 392 | 569 |
| 393 | 576 |
| 394 | 577 |
| 395 | 581 |
| 396 | 582 |
| 397 | 583 |
| 398 | 584 |
| 399 | 588 |
| 400 | 589 |
| 401 | 590 |
| 402 | 592 |
| 403 | 594 |
| 404 | 597 |
| 405 | 598 |
| 406 | 603 |
| 407 | 604 |
| 408 | 606 |
| 409 | 607 |
| 410 | 616 |
| 411 | 618 |
| 412 | 620 |
| 413 | 627 |
| 414 | 635 |
| 415 | 636 |
| 416 | 638 |
| 417 | 639 |
| 418 | 640 |
| 419 | 641 |
| 642 | |
| 644 | |
| 646 | |
| 649 | |
| 653 | |
| 654 | |
| 656 | |
| 657 | |
| 658 | |
| 660 | |
| 661 | |
| 664 | |
| 665 | |
| 667 | |
| 674 | |
| 678 | |
| 681 | |
| 682 | |
| 683 | |
| 687 | |
| 688 | |
| 689 | |
| 690 | |
| 692 | |
| 694 | |
| 696 | |
| 700 | |
| 701 | |
| 702 | |
| 703 | |
| 706 | |
| 709 | |
| 710 | |
| 713 | |
| 716 | |
| 717 | |
| 719 | |
| 721 | |
| 723 | |
| 726 | |
| 730 | |
| 731 | |
| 739 | |
| 747 | |
| 751 | |
| 754 | |
| 761 | |
| 765 | |
| 768 | |
| 772 | |
| 773 | |
| 776 | |
| 779 | |
| 784 | |
| 786 | |
| 788 | |
| 790 | |
| 792 | |
| 793 | |
| 794 | |
| 796 | |
| 799 | |
| 800 | |
| 801 | |
| 803 | |
| 804 | |
| 805 | |
| 806 | |
| 808 | |
| 809 | |
| 810 | |
| 813 | |
| 816 | |
| 817 | |
| 819 | |
| 820 | |
| 823 | |
| 824 | |
| 827 | |
| 828 | |
| 849 | |
| 851 | |
| 853 | |
| 854 | |
| 855 | |
| 861 | |
| 863 | |
| 867 | |
| 868 | |
| 883 | |
| 886 | |
| 892 | |
| 901 | |
| 907 | |
| 908 | |
| 921 | |
| 922 | |
| 925 | |
| 929 | |
| 933 | |
| 934 | |
| 936 | |
| 937 | |
| 939 | |
| 940 | |
| 941 | |
| 942 | |
| 943 | |
| 947 | |
| 949 | |
| 950 | |
| 953 | |
| 954 | |
| 955 | |
| 956 | |
| 957 | |
| 960 | |
| 962 | |
| 963 | |
| 964 | |
| 976 | |
| 977 | |
| 981 | |
| 982 | |
| 983 | |
| 985 | |
| 986 | |
| 987 | |
| 988 | |
| 990 | |
| 991 | |
| 993 | |
| 994 | |
| 997 | |
| 998 | |
| 1020 | |
| 1023 | |
| 1038 | |
| 1043 | |
| 1045 | |
| 1065 | |
| 1067 | |
| 1070 | |
| 1071 | |
| 1073 | |
| 1074 | |
| 1076 | |
| 1084 | |
| 1085 | |
| 1086 | |
| 1091 | |
| 1092 | |
| 1099 | |
| 1100 | |
| 1101 | |
| 1113 | |
| 1114 | |
| 1117 | |
| 1118 | |
| 1122 | |
| 1124 | |
| 1125 | |
| 1127 | |
| 1128 | |
| 1130 | |
| 1131 | |
| 1134 | |
| 1136 | |
| 1138 | |
| 1140 | |
| 1142 | |
| 1143 | |
| 1146 | |
| 1147 | |
| 1148 | |
| 1149 | |
| 1150 | |
| 1151 | |
| 1152 | |
| 1153 | |
| 1154 | |
| 1155 | |
| 1156 | |
| 1157 | |
| 1158 | |
| 1159 | |
| 1160 | |
| 1161 | |
| 1162 | |
| 1163 | |
| 1164 | |
| 1165 | |
| 1166 | |
| 1167 | |
| 1168 | |
| 1169 | |
| 1170 | |
| 1171 | |
| 1172 | |
| 1173 | |
| 1174 | |
| 1175 | |
| 1176 | |
| 1177 | |
| 1178 | |
| 1179 | |
| 1180 | |
| 1181 | |
| 1182 | |
| 1183 | |
| 1184 | |
| 1185 | |
| 1186 | |
| 1187 | |
| 1188 | |
| 1189 | |
| 1190 | |
| 1191 | |
| 1192 | |
| 1193 | |
| 1194 | |
| 1195 | |
| 1196 | |
| 1197 | |
| 1198 | |
| 1199 | |
| 1200 | |
| 1201 | |
| 1202 | |
| 1203 | |
| 1204 | |
| 1205 | |
| 1206 | |
| 1207 | |
| 1208 | |
| 1209 | |
| 1210 | |
