3 min read

In The News:  ROSALIND welcomes partners HELiXrUS and Geninus

By Arizona Milotich on Apr 15, 2021 8:35:57 AM

These new partnerships are intended to bring powerful new Single Cell Analysis Services to Cancer Researchers. ROSALIND adds a Web-based solution to offer advanced biological analysis and interpretation of Single Cell Clusters in tumor genome profiling experiments. 

Topics: Cancer BioInformatics Rosalind Public Data Collaboration Single Cell Partnerships
4 min read

In The News:  NEW COVID-19 Variant Monitor SYSTEM

By Tim Wesselman on Mar 23, 2021 4:19:53 PM

This new web-based system, developed with NIH funding, will aid in monitoring emerging SARS-CoV-2 variants and the performance of diagnostic tests

Topics: BioInformatics Rosalind Public Data Collaboration COVID-19
5 min read

NEW ROSALIND Single Cell Solution

By Jay Gerlach on Mar 2, 2021 6:47:15 AM

This first-of-its-kind solution delivers end-to-end single-cell analysis in an intuitive web-based interface

Topics: Rosalind Collaboration Search Intelligence
3 min read

Our new corporate identity

By Tim Wesselman on Mar 1, 2021 10:35:03 AM

In Her Honor...    

Topics: Rosalind Collaboration Search Intelligence
9 min read

Remote Learning with ROSALIND

By Arizona Milotich on Feb 11, 2021 12:47:57 PM

An Interview with Janice and Harrison of Jericho High School

3 min read

How Knowledge Graphs Shape the Future of Discovery

By Tim Wesselman on Jan 14, 2021 6:15:00 AM

Knowledge Graph architecture unifies information and creates a foundation for FAIR (Findable Accessible Interoperable and Reusable) data management and advanced search capabilities. The impact for research is an exponential expansion and acceleration in extracting insights.

Topics: Rosalind Collaboration Search Intelligence
3 min read

Getting More Out of Single Cell Experiments with ROSALIND®

By Jay Gerlach on Nov 10, 2020 8:20:56 AM

Single Cell Gene Expression studies are becoming an essential tool for understanding the complex interplay of cells in both healthy and diseased tissue. Thanks to huge strides forward in technologies enabling the partitioning and sequencing of individual cells, we are seeing an explosion of new Single Cell studies across a variety of fields. In many cases, it seems that the ability to produce data is outpacing the ability extract meaning from the data. ROSALIND is seeking to close this gap by accelerating upstream data processing and providing an intuitive user interface for downstream analysis of cell clusters.

ROSALIND utilizes cloud-scale data processing and an intuitive graphical user interface to make processing of 10x Genomics cell ranger datasets both faster and easier. Alignment, quantification, and download of default clustering results can be performed easily by non-expert users without the need for onsite computer processing power.

ROSALIND also supports downstream analysis of cell clusters generated in the 10x Loupe Browser. Cell clusters defined in Loupe can be compared with one another at the level of individual genes, pathways, drugs, other key terms. This unlocks the next era of Single Cell research which will focus on developing deep understanding of the biology of each cell type cluster in a given context and the identification of actionable markers.

 

We are excited to participate in the Single Cell Sequencing revolution and look forward to building on the capabilities we have already established by responding to the needs of our user base. We encourage you to try ROSALIND’s new Single Cell Analysis features and let us know what you think.  Video tutorials can be found within the ROSALIND user interface and we are available to perform demos of the new functionality.

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Topics: Transcriptome BioInformatics Rosalind Pathways
2 min read

Making the invisible… visible.

By Cassandra Wesselman on Nov 6, 2020 12:31:54 PM

What is Corporate Leadership? While operating responsibly should always take priority, Corporate Leadership requires us to focus on the very nature of our activities, going even deeper than our actions around Corporate Social Responsibility. This aspect of leadership defines the character of an entity, the impressions often left in its wake, and holds the tone across the organization and all its choices.

In the Life Sciences industry, corporations have unique advantages that smaller research and academic institutions often struggle with: resources and velocity. Private Equity and income generation provide more attainable financial support, and dedicated teams with cyclical workstreams allow for expediency when reaching for outcomes. The effective application of these resources to timely and impactful initiatives related to human health, environmental science, and the convergence of biology and technology is crucial for corporations looking to lead our society towards a better world.

Corporate leadership also paves the path forward to enable those who will hold the torch of leadership. This includes whose and what programs are supported and uplifted to succeed and allocating resources to focus on important efforts that help make what may have been unseen, acknowledged.

OnRamp is proud to be a founding member of the Rosalind Franklin Society’s Council on Corporate Leadership. This Council focuses on recognizing and fostering the contributions of women and minorities across scientific professions and institutions. The importance of fostering such work is fundamental to our core values, having named our flagship product, ROSALIND®, in honor of Rosalind Franklin and her pioneering spirit as we strive to empower all scientists in collaborative discoveries that transform our world.

The mission of the Council on Corporate Leadership is to create a more diverse landscape for scientific achievements, in a way that powerfully recognizes important work by every scientist.    

In the coming months, the Council on Corporate Leadership will be building its base of corporate partners and engaging them on strategies to recognize great achievements while addressing inequities of women and minorities in science. The Council will convene at a dedicated colloquium during the RFS annual board meeting this December, featuring Nobel Laureates, senior scientists as well as young researchers and leaders of promise. The Council will also be supporting the financing and allocation of the Rosalind Franklin Award given annually to pioneering women in the industrial, biotechnology and agriculture sectors who have made significant contributions to the advancement of the bio-based economy and biotech innovation.

OnRamp is very excited to be part of this important new initiative and we encourage our colleagues to get involved. Those interested in becoming a corporate partner should reach out to Cassandra Wesselman by emailing: cassandra@rosalind.bio

Topics: Transcriptome BioInformatics Rosalind Pathways
2 min read

Term-based Exploration - Deeper Insights with Gene Set Variation Analysis

By Tim Wesselman on Oct 27, 2020 8:13:36 AM

Opening a new door to discovery, ROSALIND now empowers scientists to explore experiment results by key terms (Pathways, Signatures, Diseases and Drugs) that are significantly enriched across all samples using GSVA scores. You can access Term Exploration within the Discovery and Analysis section of each experiment. ROSALIND has been pre-computing these scores for the past several months, so many existing experiments already have this new analysis ready for exploration.

Every experiment and scientific question seeks to find insights on biological processes and pathways. Prior to now, this scientific journey always began with an exploration of genes to uncover the changes to underlying pathways. Now, you can begin exploring Pathways and significant Terms regardless of comparisons or cut-offs.

Topics: Transcriptome BioInformatics Rosalind Pathways
2 min read

Jay Gerlach and Sam Kim

By Tim Wesselman on Oct 8, 2020 4:13:38 PM

Jay Gerlach, VP Strategic Marketing and Alliances

Jay Gerlach joins us as VP of Strategic Marketing and Alliances. Previously, Jay led the nCounter product line at NanoString where he enjoyed an incredible 10 year career. Having started with NanoSting when they had fewer than 40 employees, Jay was instrumental to the growth, culture and development of the nCounter Analyzer. He brings deep commercial and product management expertise together with natural leadership and communication skills. He is deeply passionate about transforming scientific discovery to accelerate our realization of Precision Medicine.     

Topics: BioInformatics Rosalind Collaboration NanoString Our Team
5 min read

ROSALIND® for nCounter Users

By Tim Wesselman on Oct 8, 2020 7:56:51 AM

October 08, 2020 09:33 AM Eastern Daylight Time
Topics: BioInformatics Rosalind Collaboration NanoString
4 min read

ROSALIND v3.16: Enhanced Collaboration and Pathways

By Jeremy Davis-Turak on Jun 26, 2020 7:28:36 PM

Our latest ROSALIND update v3.16 is now live and delivers enhancements for collaboration, 10X Single Cell RNA (scRNA-seq), Pathway Enrichment and more.

Topics: BioInformatics Rosalind Public Data Collaboration COVID-19
3 min read

Lexogen Partners for QuantSeq 3' Analysis & Collaboration

By Tim Wesselman on Jun 17, 2020 5:04:17 PM

VIENNA and SAN DIEGO, June 17, 2020 /PRNewswire/ -- Lexogen, a transcriptomics and Next Generation Sequencing company, and OnRamp Bioinformatics, a provider of cloud-based genomic analysis and collaboration tools, announced availability for the QuantSeq 3' mRNA-Seq data analysis pipeline on ROSALIND™, the globally recognized discovery platform for scientists and researchers. The partnership enhances QuantSeq 3' mRNA-Seq data analysis with ROSALIND's visual data exploration and deep pathway interpretation with more than 50 knowledge bases.

Topics: BioInformatics Rosalind RNAseq Collaboration
2 min read

Canopy Partners with OnRamp Bio for Interactive Data Analysis & Real-Time Collaboration

By Tim Wesselman on Jun 17, 2020 3:51:55 PM

St. Louis, MO /PR Newswire/—Canopy Biosciences, a multi-omic CRO providing NanoString® nCounter® and RNA Seq services to both clinical and research customers, has partnered with Onramp BioInformatics™ to offer their ROSALIND™ interactive data analysis platform for Canopy’s gene expression services.  Launched earlier this year, Canopy has been providing this intuitive platform to customers that have run NanoString and RNA Seq projects.

Topics: BioInformatics Rosalind RNAseq Collaboration NanoString
3 min read

Multi-Omics for Every Scientist

By Jean Lozach on Jun 2, 2020 7:29:21 AM

I’m convinced, and I know most of you are too, that we will not get to a complete understanding of diseases and biology in general without looking behind a multi-omics lens. While NGS radically democratized access to genomics information with RNA-seq, for example, the complexity of other assays like ChIP-seq and the ensuing challenges in combining different types of data analyses have limited the wide scale adoption of multi-omics approaches.

Topics: BioInformatics GenomeWeb Epigenetics Meta-Analysis Collaboration
5 min read

NanoString-OnRamp Bio Partnership

By Tim Wesselman on May 21, 2020 7:53:18 PM

NanoString and OnRamp BioInformatics Partner to Develop Cloud-Based Analysis Solutions for nCounter Data

Expanded Functionality to Support COVID-19 Research
Immediately Available Through Early Access

May 20, 2020 09:00 AM Eastern Daylight Time

SEATTLE--()--NanoString Technologies, Inc. (NASDAQ:NSTG), a leading provider of life science tools for discovery and translational research, and OnRamp Bioinformatics, a provider of cloud-based genomic analysis tools, today announced a collaboration for the development of new analysis tools for data generated on NanoString’s nCounter® Analysis System. The new analysis functionality is built into ROSALIND™, OnRamp’s cloud-based analysis suite that facilitates data visualization, exploration and collaboration. The companies are releasing these new capabilities through early access and immediately offering it to COVID-19 researchers performing critical host response studies on the nCounter platform.

Topics: BioInformatics Rosalind Collaboration COVID-19
4 min read

COVID19 Support and Pathway Enhancements

By Tim Wesselman on Apr 15, 2020 11:27:20 AM

 

Topics: BioInformatics Rosalind Public Data Collaboration COVID-19
4 min read

Remote Science in the Era of Social Distancing

By Tim Wesselman on Mar 26, 2020 1:11:50 PM

We’ve all been reminded across various social media feeds how Isaac Newton discovered calculus while “social distancing” during the Great Plague of London or how some of Shakespeare’s greatest works happened while in quarantine. Although the thought of being able to work from home was once a dream we wished for, as Adam Ruben, Ph.D. puts it, science-ing from home isn’t easy.

If juggling your altered home-life alongside the 9-5 work routine wasn’t challenging enough, it’s even more questionable how you can advance your research now that you have limited access to your laboratory, your data and your team.

As we all grapple with the new reality of lockdowns and work-from-home mandates, there’s now a new opportunity re-define what it truly means to do collaborative research and remote science anywhere in the world.

Topics: BioInformatics Rosalind Public Data Collaboration COVID-19
7 min read

Join the COVID-19 Research Community

By Tim Wesselman on Jan 25, 2020 1:14:00 PM

Updated: June 25, 2020 ------
The COVID-19 Research Community Showcase

The COVID-19 Research Community unites scientists across the globe in the shared purpose of accelerating our collective understanding of COVID-19 and the SARS-CoV-2 virus. Researchers working on COVID-19 receive complimentary Community Scientist access to ROSALIND and the NanoString Early Access Program to facilitate rapid data analysis with real-time, global collaboration.

Today, we enhanced the COVID-19 Research Community through the addition of a new Showcase. ROSALIND Showcases provide a new experience for collaboration by summarizing highlights, capturing key observations and empowering community scientists with a library of COVID-related datasets, including some of the most recent research. 

The COVID-19 Research Community Showcase is accessible publicly at this link: https://rosalind.onramp.bio/showcase/covid19

Join the community effort to share, discover and accelerate our collective understanding of COVID-19.

Updated: May 20, 2020 ------
NanoString Early Access Program and the COVID-19 Community

Today, we announced our collaboration with NanoString for the development of new analysis tools for data generated on NanoString’s nCounter® Analysis System. This new analysis functionality is now built into ROSALIND™ and facilitates data visualization, exploration and collaboration for COVID-19 researchers performing critical host response studies on the nCounter platform.

As of the Early Access Program launched today, ROSALIND natively supports the NanoString COVID Panel Plus with targeted gene expression on human immune response with 10 supplemental genes (8 SARS-CoV-2 plus ACE2 human and ACE2 mouse). This new solution incorporates the methods and algorithms of NanoString nSolver and their Advanced Analysis solution within ROSALIND to accelerate insights from the nCounter instrument and empower global collaboration. 

Through the Early Access Program scientists and researchers are empowered with an end-to-end solution that streamlines the extraction, quantification, data analysis and collaboration to provide deeper insights into the gene expression of human immunology together with the viral response experienced during COVID-19.   

Updated: April 12, 2020 ------
COVID-19 Community Enablement - SARS-CoV-2 Genome & Virology

The SARS-CoV-2 genome is now available for new experiments and to support the COVID-19 Community. This facilitates analysis and discovery into the viral gene expression of COVID-19. Many of the recent NCBI public data submissions with SARS-CoV-2 samples and COVID-19 patient samples have already been processed and added to the Community Space.

ROSALIND Pathways has added a new Virology category and collection of Knowledge Bases to enhance COVID-19 research. New entries include Pathogen-Host Interactome (P-HIPSTer) and GEO Virus Perturbations. 

New COVID-19 datasets now available in the Community Space:

  • Transcriptional response of human lung epithelial cells to SARS-CoV-2 infection (PRJNA615032)
  • LY6E blocks coronavirus fusion and confers immune control of viral disease (PRJNA609134)
  • Washington SARS-CoV-2 isolate sequences (PRJNA610428)
  • Severe acute respiratory syndrome coronavirus 2 Raw sequence reads (PRJNA605983)
  • Metatranscriptomics of two COVID-19 pneumonia cases (PRJNA601736)
  • Relative timing of type I interferon response and virus replication determines disease outcome during MERS-CoV infection (PRJNA545350)

Updated: March 30, 2020 ------
Support for the SARS-CoV-2 Genome is in development now and will be released next week. We will also be posting several new public datasets from multiple locations across the globe. It's imperative that we join forces globally in open data sharing on COVID-19 so that we may track the strains, measure the progression of the disease and assess the efficacy of treatments.

If you have COVID-19 datasets, upload them today for free processing and interpretation.


Originally Posted: Jan 25, 2020 ------

Seeing the news on the growing threat of a Coronavirus pandemic, I’m reminded of just how interconnected we all are on this planet. Within a few short weeks, this deadly virus managed to make its way across species and oceans to a dozen different countries, affecting thousands of people. We still don’t know how severe this strain of Coronavirus will be and it’s hard not to be driven to join the fight against it.

We live in an era of unprecedented genomic technology with brilliant scientists that work tirelessly each day to gain deeper understanding into the inner workings of our biology and the diseases that afflict us. I believe that our greatest work stands before us and will be achieved through collaboration. While technical, organizational or resource constraints often slow our progress in other areas, we can overcome these now to collaborate for the cure.

Today we've launched the Coronavirus Community Space to provide open-access of ROSALIND, our discovery and collaboration platform, for fellow scientists who wish to join a community effort to share, discover and accelerate our collective understanding of Coronavirus.

JOIN THE CORONAVIRUS COMMUNITY SPACE

 

Topics: Rosalind Collaboration Gene Signatures Pathways Community
3 min read

The Value is in Collaboration (not the pipeline)

By Tim Wesselman on Sep 11, 2019 3:38:21 PM

After conversations with thousands of Scientists, there is stunning lesson in their feedback that every Pharma and Biotech manager should internalize: Collaboration is more valuable than the underlying analysis pipelines.

No matter how great the pipeline, if Scientists can’t explore, interpret and consistently collaborate on a common version of the data then the value invested in the experiment is lost, or simply not realized.

Like dark data, the latent insights in these experiments remain trapped. Interestingly, Pharma and Biotech institutions with a deluge of clinical trial and research data are looking for collaboration tools for their Scientists, not the fundamental analysis pipelines. The implications for oncology research, immunology, drug discovery and disease research are significant.

Topics: BioInformatics Rosalind Public Data Collaboration
6 min read

Collaborating on Genomic Data (like Google Docs)

By Tim Wesselman on Aug 9, 2019 7:18:00 AM

Let’s face it, collaborating on genomics data is hard.

Topics: Rosalind Public Data Collaboration
89 min read

Empowering Scientists with the ROSALIND Platform

By Tim Wesselman on Jul 19, 2019 8:18:00 AM

Thousands of Scientists around the world entrust ROSALIND every day to discover the most valuable results in their NGS data and to enable collaboration across project teams and labs. ROSALIND provides  fast, easy data processing and is recognized as the leading Scientist-focused platform for genomic analysis and collaboration.  

In this post, I'll review ROSALIND's latest capabilities, supported species and experiment types as well as our new subscription plans designed specifically for Scientists and Biologists. 

  • In case you missed it, we recently provided a detailed walk-through on Public Data exploration. Follow this link for more information.
  • As well as the ability to Collaborate on Genomic Data as easily and in real-time like Google Docs. Follow this link for more information. 
  • NanoString recently announced a collaboration for the development of new analysis tools for data generated on NanoString’s nCounter® Analysis System. The new analysis functionality is built into ROSALIND and will soon be available to all NanoString customers. Learn more and join the Early Access Program.
Topics: BioInformatics Rosalind Epigenetics RNAseq Public Data
2 min read

Poster: Genomic Modalities to Drug Development for S. Mansoni

By Jean Lozach on Jul 16, 2019 8:05:48 PM


Schistosoma mansoni causes schistosomiasis, a disease of poverty that infects approximately 200 million people worldwide. Treatment of the disease relies on praziquantel (PZQ). With the expanding use of the drug, there is a fear over the development of resistance. It is, therefore, important to discover new drugs and drug targets.

I'm really happy to announce  another poster and research project utilizing ROSALIND, our analysis and collaboration platform for genomics.

Topics: BioInformatics Rosalind RNAseq Collaboration UCSD
2 min read

Public Data Analysis and Exploration, Re-invented.

By Tim Wesselman on Jul 13, 2019 7:33:00 AM


Working with Public Data is important to nearly every Scientist in our community. Unfortunately, it's harder than it should be to work with these valuable datasets.  We all see and hear the news each week of exciting discoveries and breakthroughs in leading research, yet accessing and analyzing these Public Datasets, especially from RAW (SRA), requires determination, persistence and more coding skills than should be required of Scientists today.

Topics: BioInformatics Rosalind RNAseq miRNA-seq NCBI Public Data
3 min read

Active Motif & OnRamp Announce Partnership

By Jeremy Davis-Turak on Dec 12, 2018 7:37:00 AM

OnRamp’s ROSALIND and Active Motif offer an improved ChIP-Seq data analysis experience for researchers with state-of-the-art dynamic track plots and advanced collaboration capabilities.

FOR IMMEDIATE RELEASE

San Diego, California – December 12, 2018 - OnRamp BioInformatics, a genomics company focused on scientist-friendly bioinformatics software solutions, today announced they are working with Active Motif to improve accuracies in data analysis for ChIP-Seq experiments.

OnRamp’s flagship software, ROSALIND, provides a point-and-click experience to speed up and simplify the process of genomic data analysis from experiment setup to QC and interactive data visualization to interpretation. With this integration, researchers will now benefit from an optimized analysis that includes the unique characteristics of Active Motif kits and antibodies, including Unique Molecular Identifiers (UMI) and spike-in solutions.

Download The One-Sheet

Topics: Big Data Personalized Medicine Cancer BioInformatics Biology Rosalind advaita
2 min read

ROSALIND WINS BEST OF SHOW AT BIO-IT WORLD 2018

By Jean Lozach on Jun 8, 2018 9:43:00 AM

OnRamp takes home the "People's Choice - Best of Show" award at BioIT-World 2018 in Boston.
Click here to try ROSALIND for free
Topics: Personalized Medicine Transcriptome BioInformatics Rosalind Epigenetics
4 min read

Come See ROSALIND at Bio-IT World 2018

By Jean Lozach on May 11, 2018 1:52:23 PM

As proud contender for Bio-IT World's "People's Choice - Best in Show", ROSALIND will have latest features presented throughout the event

Event: Bio-IT World

Dates: 5/15/18 - 5/17/18

Location: Seaport World Trade Center, Boston MA

Event URL: www.bio-itworld.com/

Topics: Personalized Medicine Transcriptome BioInformatics Rosalind Epigenetics
1 min read

View Our Meta Analysis Webinar

By Jeremy Davis-Turak on May 9, 2018 9:19:00 AM

Building a "Comparison of Comparisons" Across Multiple Experiments using Meta-Analysis on ROSALIND

Topics: Transcriptome BioInformatics Webinar RNAseq
4 min read

Decoding Human Health

By Jeremy Davis-Turak on May 3, 2018 9:10:20 AM

OnRamp and Advaita announce a Strategic Partnership to bring collaboration and widespread accessibility to genomic data analysis

San Diego, CA – May 3, 2018 OnRamp Bioinformatics, Inc., a genomics company providing the premier scientist-focused data analysis platform, and Advaita BioInformatics, a leader in personalized medicine and interpretation of Next-Gen Sequencing data, announced they are partnering to provide a comprehensive research experience from sample to interpretation with a seamless handoff between systems.  

OnRamp.Bio’s flagship product, ROSALIND™, enables researchers, drug developers and bench scientists to analyze raw genomics data by providing a transformative experience through point-and-click experiment set up, interactive data visualization and interpretation. This new approach increases productivity by freeing up time for the bioinformatician to focus on more challenging workloads, while making bioinformatic analysis more accessible for the scientist to do more discovery with their data.

Topics: Big Data Personalized Medicine Cancer BioInformatics Biology Rosalind advaita
1 min read

ROSALIND Featured at #TRICON 2018!

By Jean Lozach on Feb 6, 2018 1:29:39 PM

OnRamp's CEO, Tim Wesselman, features ROSALIND™ during Plenary Keynote Panel on Emerging Technologies and Industry Perspectives

Event: Molecular Medicine Tri-Conference

Date/Time: February 14th @ 8:45a PT

Location: San Francisco Moscone Convertion Hall

Event URL: http://www.triconference.com/

Topics: Personalized Medicine Transcriptome BioInformatics Rosalind Epigenetics
2 min read

RNA-seq Webinar

By Gary Hardiman on Dec 7, 2017 8:48:50 PM

In this webinar, we discussed the transcriptomic analysis of racial disparities in prostate cancer using OnRamp's ROSALIND™ platform

Topics: Transcriptome BioInformatics Webinar RNAseq
3 min read

OnRamp Featured in Huffington Post

By Dr. Robi Ludwig on Nov 17, 2017 1:13:11 PM

Dr. Robi Ludwig interviews OnRamp CEO, Tim Wesselman, to explore the future needs for genomics to scale.

Tim Wesselmanthe Chief Executive Officer of OnRamp.Bio, is on a mission to streamline, simplify and revolutionize the way we currently analyze and store genomic data, the data found within the DNA of every living thing.

You might be thinking, why is this so important? Well, this form of analysis allows researchers, biologists and drug developers to access the genomic information they need, which will permit them to achieve greater discoveries; discoveries that will benefit both individuals and society.

Wesselman spent the last two decades as a senior executive in top technology companies working on next generation data management and storage solutions (called hyper-scale). He is a graduate of multiple executive programs in Finance, Accounting, Investor Relations and Strategic Marketing from Columbia University, Rice University and University of Michigan and holds a B.S. Mechanical Engineering degree from Texas A&M University. Wesselman believes that software innovation will allow researchers to be in control of their own research, in a way that they aren’t now, enabling them to operate at a speed more in sync with today’s modern world’s pace: A pace which is becoming exponentially faster all of the time.

After a frightening experience Tim Wesselman had with the safety of his third unborn child who was medically at risk, he became even more determined to improve upon the research around this scientific quagmire when it came to obtaining genomic results for personalize medicine and patient care. The incident concerning his unborn child further underscored his belief that the inner secrets of life encoded in DNA, especially when it comes to disease and environment, are far too important to not be translated in a way that makes the most sense. In a way that facilitates the greatest minds of our time to find the answers, cures, and treatment impacting our current and future society.

Tim Wesselman and I got into more details about this intriguing and very modern scientific topic during our interview here.

Topics: Big Data Personalized Medicine Cancer BioInformatics Biology Rosalind
1 min read

OnRamp’s Rosalind™ overcomes limitations found in existing data analysis tools

By Jean Lozach on Oct 11, 2017 3:19:41 PM

Our mission is to transform how cancer researchers and biologists analyze their data (at SCALE)!

Advanced bioinformaticians deserve all of the credit for building state-of-the-art applications to analyze genomic, proteomic, and microarray data.  While these tools remain the lifeline of genomic analysis, more simplified user experiences are now required to empower today’s cancer biologists to focus on their research application, not which software application to use. 

Topics: Big Data Cancer Pipelines BioInformatics Biology Rosalind
1 min read

Meet  Rosalind™ in Orlando at ASHG 2017!

By Tim Wesselman on Oct 4, 2017 1:58:00 PM

OnRamp BioInformatics welcomes you to visit us at the ASHG Data CoLab zone Oct 18th, 19th and 20th to Meet Rosalind™. 

This new platform was built with the researcher/biologist in mind, guiding you through a simplified bioinformatics process from experimental design to interpretation for analyses including transcriptomics and epigenetics. 

Topics: Personalized Medicine Transcriptome BioInformatics Rosalind Epigenetics
4 min read

OnRamp Featured in GenomeWeb

By Neil Versel on Jul 20, 2017 1:28:27 PM

Cloudian, OnRamp, ScaleMatrix Partnership Eyes Faster, Lower-Cost Genome Analysis.

Written By: Neil Versel

CHICAGO (GenomeWeb) - When ScaleMatrix, OnRamp Bioinformatics, and Cloudian decided to get together in an effort to speed up sequencing analysis and lower the cost of data storage, they saw several shortcomings in the genomic informatics market.

Topics: BioInformatics Cloudian GenomeWeb ScaleMatrix
3 min read

Complexity & Data Sharing

By Tim Wesselman on May 15, 2017 12:49:00 PM

Good News Bad News for Personalized Medicine.

I’m reminded daily of the many advancements towards personalized medicine, but one elephant remains firmly planted in the room.

Recently I came across an encouraging article that touched on the increasingly collaborative nature of the efforts to bring about this new age of personalized medicine.  Data-sharing is reported to be on the rise in oncology, with groups like the Genomic Data Commons assembling harmonized genomic and clinical datasets, and making that information widely accessible to cancer researchers. 

Topics: Big Data Personalized Medicine
2 min read

Pipelines & Data Integration

By Jeremy Davis-Turak on Feb 15, 2017 10:36:00 AM

Challenges and opportunities in the research setting. 

The emergence and mass utilization of high-throughput (HT) technologies, including sequencing technologies (genomics) and mass spectrometry (proteomics, metabolomics, lipids), has allowed geneticists, biologists, and biostatisticians to bridge the gap between genotype and phenotype on a massive scale. These new technologies have brought rapid advances in our understanding of cell biology, evolutionary history, microbial environments, and are increasingly providing new insights and applications towards clinical care and personalized medicine.

Topics: Big Data Pipelines BioInformatics Genomic Data Management
2 min read

MICROBIOMES & OUR HEALTH

By Jeremy Davis-Turak on Dec 19, 2016 1:30:00 PM

Could health outcomes be determined by the little guys who call us home?

The San Diego MicroBiome Meetup, hosted by Clotide Telling of Illumina, Inc., kicked off with a presentation by OnRamp's Scientific Advisor, Rob Edwards. Rob's story of the discovery of the crAssphage is a truly amazing example of Metagenomics and the MicroBiome, and is testament to the power of the sequencing revolution.

Topics: microbiome crAssphage San Diego State University
4 min read

Prostate cancer, racial disparities and Vitamin D3

By Gary Hardiman on Nov 16, 2016 10:18:00 AM

Transcriptome differences in prostate cancer highlight racial disparities. 

African-American and European-American men with prostate cancer exhibit significantly different expression of genes associated with immune response and inflammation.

Systems-level, RNA analyses support the concept that inflammatory processes may contribute to racial disparities in disease progression and that vitamin D3 supplementation can modulate pro-inflammatory transcripts.

Topics: Cancer BioInformatics Genomic Data Management
3 min read

Horizon Oil Spill Effects on Mahi-Mahi (insights powered by OnRamp)

By Jeremy Davis-Turak on Jul 20, 2016 9:38:00 AM

The threat to fish embryos and larvae development.

MIAMI-A research team led by scientists at the University of California, Riverside and the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science have found that ultraviolet light is changing the structure of the Deepwater Horizon (DWH) oil components into something more toxic, further threatening numerous commercially and ecologically important fishes.

Topics: BioInformatics Genomic Data Management
2 min read

OnRamp Featured in Frontline Genomics Magazine

By Jeremy Davis-Turak on Jan 20, 2016 11:44:00 AM

Click here to read the full interview.

Topics: Big Data BioInformatics Genomic Data Management